Liu Lab - UC Davis

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Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging.

Kim, Min-Ho Liu, Wei Borjesson, Dori L Curry, Fitz-Roy E Miller, Lloyd S Cheung, Ambrose L Liu, Fu-Tong Isseroff, R Rivkah Simon, Scott I

Published in The Journal of investigative dermatology

Neutrophil influx is an early inflammatory response that is essential for the clearance of bacteria and cellular debris during cutaneous wounding. A non-invasive real-time fluorescence imaging technique was developed to examine the kinetics of enhanced green fluorescence protein-polymorphonuclear leukocyte (EGFP-PMN) influx within a wound. We hypot...

Melanocytic galectin-3 is associated with tyrosinase-related protein-1 and pigment biosynthesis.

Chalupa, Allison Koshoffer, Amy Galan, Emily Yu, Lan Liu, Fu-Tong Boissy, Raymond E

Published in The Journal of investigative dermatology

Galectin-3 is a family member of the carbohydrate-binding proteins widely expressed by many cell types and exhibits multiple cellular functions. We demonstrate that melanocytes express galectin-3, which is predominantly localized to the cell body peripherally along the Golgi zone. Downregulation of galectin-3 in human melanocytes using short hairpi...

Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling.

Chen, Hung-Lin Chiang, Po-Cheng Lo, Chia-Hui Lo, Yuan-Hsin Hsu, Daniel K Chen, Huan-Yuan Liu, Fu-Tong

Published in The Journal of investigative dermatology

Galectin-7, a member of the β-galactoside-binding protein family, is primarily expressed in stratified epithelial cells, including keratinocytes. There is information in the literature suggesting a role for this protein in regulation of keratinocyte survival and growth, but the underlying mechanism remains relatively unknown. Moreover, its expressi...

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