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Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs ... PDF available through Get Fulltext Research

Arsenijevic, Aleksandar Milovanovic, Marija Milovanovic, Jelena Stojanovic, Bojana Zdravkovic, Natasa Leung, Patrick S C Liu, Fu-Tong Gershwin, M Eric Lukic, Miodrag L

Published in Scientific reports

Galectin-3 (Gal-3) is a carbohydrate binding lectin, with multiple roles in inflammatory diseases and autoimmunity including its antiapoptotic effect on epithelial cells. In particular, increased expression of Gal-3 in epithelial cells is protective from apoptosis. Based on the thesis that apoptosis of biliary epithelial cells (BECs) is critical to...

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