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Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori. PDF available through Get Fulltext Research

Park, Ah-Mee Hagiwara, Satoru Hsu, Daniel K Liu, Fu-Tong Yoshie, Osamu

Published in Infection and immunity

We studied the role of galectin-3 (Gal3) in gastric infection by Helicobacter pylori We first demonstrated that Gal3 was selectively expressed by gastric surface epithelial cells and abundantly secreted into the surface mucus layer. We next inoculated H. pylori Sydney strain 1 into wild-type (WT) and Gal3-deficient mice using a stomach tube. At 2 w...

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