Publication search

The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth.

Published in Cancer Research

Fibrinogen is a major plasma protein (350 kDa) that induces proliferative signals by serving as a scaffold to support the binding of growth factors and to promote the cellular responses of adhesion, proliferation, and migration during wound healing, angiogenesis, and tumor growth. Fibrin(ogen) degradation products generated during fibrinolysis are ...

Suppression of tumor growth by galectin-7 gene transfer.

Published in Cancer Research

Galectin-7 is a beta-galactoside-binding animal lectin specifically expressed in stratified epithelia. Its expression is inducible by p53 and is down-regulated in squamous cell carcinomas. Other investigators previously showed that galectin-7 is a proapoptotic protein, and we showed that ectopic expression of galectin-7 in HeLa cells renders the ce...

Suppressive effect of galectin-7 on tumor growth

Published in Cancer Research