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Engineered nanostructures of antigen provide an effective means for regulating mast cell activation.

Deng, Zhao Weng, I-Chun Li, Jie-Ren Chen, Huan-Yuan Liu, Fu-Tong Liu, Gang-yu

Published in ACS nano

Nanostructures containing 2,4-dinitrophenyl (DNP) as antigen were designed and produced to investigate antibody-mediated activation of mast cells. The design consists of nanogrids of DNP termini inlaid in alkanethiol self-assembled monolayers (SAMs). Using scanning probe-based nanografting, nanometer precision was attained for designed geometry, si...

Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukem...

Li, Jr Ross, Ss Liu, Y Liu, Yx Kang-Hsin Wang Huan-Yuan Chen Fu-Tong Liu Laurence, Ta Liu, Gy

Published in ACS Nano

A recent finding reports that co-stimulation of the high-affinity immunoglobulin E (IgE) receptor (FcεRI) and the chemokine receptor 1 (CCR1) triggered formation of membrane nanotubes among bone-marrow-derived mast cells. The co-stimulation was attained using corresponding ligands: IgE binding antigen and macrophage inflammatory protein 1α (MIP1 α)...

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Engineered nanostructures of antigen provide an effective means for regulating mast cell activation.

Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukem...