Modulation of CD6 function through interaction with Galectin-1 and -3.

Published in FEBS Letters

CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian le...

B cell depletion therapy exacerbates murine primary biliary cirrhosis.

Published in Hepatology

Evaluation and comparison of store-and-forward teledermatology applications.

Published in Telemedicine and e-Health

A review of pityriasis rubra pilaris and rheumatologic associations.

Published in Clinical and Developmental Immunology

Pityriasis rubra pilaris (PRP) is a rare group of hyperkeratotic, papulosquamous disease that can be acquired or inherited. There have been reported cases of rheumatologic associations, mainly arthritis and dermatomyositis. In this review article, we will explore the clinical presentation and classification, rheumatologic associations and treatment...

Galectins: novel anti-inflammatory drug targets.

Published in Expert Opinion on Therapeutic Targets

Galectins are a protein family defined by their affinity for beta-galactosides and consensus sequences. They are pleiotropic regulators involved in a multitude of functions, both in and out of the cell. Extracellularly, they have the potential to bind to various surface receptors on a variety of cell types as well as extracellular matrix (ECM) prot...

Hedgehog signaling pathway mediates tongue tumorigenesis in wild-type mice but not in Gal3-deficient mice.

Published in Experimental and Molecular Pathology

Oral squamous cell carcinoma (OSCC) is one of the most aggressive cancers of the oral cavity and an important cause of death worldwide. Currently, there are limited clinical tools aiding clinicians to establish its early diagnosis, and genetic and epigenetic events leading to the pathogenesis of OSCC remain unsolved. The use of carcinogen-induced k...

Frontline Science: Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while pro...

Published in Journal of Leukocyte Biology

Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds.

Published in Journal of Biological Chemistry

Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem. These conditions affect many tissues, are painful, and are difficult to treat. In this study, using cornea as a model, we demonstrate for the first time the importance of carbohydrate-binding proteins galectins-3 and -7 in re-epitheli...

Applications of atomic force microscopy in biophysical chemistry of cells.

Published in The Journal of Physical Chemistry B

This article addresses the question of what information and new insights atomic force microscopy (AFM) provides that are of importance and relevance to cellular biophysical chemistry research. Three enabling aspects of AFM are discussed: (a) visualization of membrane structural features with nanometer resolution, such as microvilli, ridges, porosom...

Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis....

Published in PLoS ONE

Galectin-12, a member of the galectin family of β-galactoside-binding animal lectins, is preferentially expressed in adipocytes and required for adipocyte differentiation in vitro. This protein was recently found to regulate lipolysis, whole body adiposity, and glucose homeostasis in vivo. Here we identify VPS13C, a member of the VPS13 family of va...