Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukem...

Published in ACS Nano

A recent finding reports that co-stimulation of the high-affinity immunoglobulin E (IgE) receptor (FcεRI) and the chemokine receptor 1 (CCR1) triggered formation of membrane nanotubes among bone-marrow-derived mast cells. The co-stimulation was attained using corresponding ligands: IgE binding antigen and macrophage inflammatory protein 1α (MIP1 α)...

Regulation of cellular homeostasis by galectins.

Published in Glycoconjugate Journal

Members of the galectin family are presently known to participate in cellular homeostasis by modulating cell growth, controlling cell cycle progression, and inducing or inhibiting apoptosis. Both intracellular and extracellular activities of galectins have been described, with the former typically independent of lectin activity, and the latter medi...

Regulatory roles of galectins in the immune response.

Published in International Archives of Allergy and Immunology

Galectins are a family of animal lectins with affinity for beta-galactosides. They are differentially expressed by various immune cells and their expression levels appear to be dependent on cell differentiation and activation. They can interact with cell-surface and extracellular matrix glycoconjugates (glycoproteins and glycolipids), through lecti...

Modulation of CD6 function through interaction with Galectin-1 and -3.

Published in FEBS Letters

CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian le...

B cell depletion therapy exacerbates murine primary biliary cirrhosis.

Published in Hepatology

Evaluation and comparison of store-and-forward teledermatology applications.

Published in Telemedicine and e-Health

A review of pityriasis rubra pilaris and rheumatologic associations.

Published in Clinical and Developmental Immunology

Pityriasis rubra pilaris (PRP) is a rare group of hyperkeratotic, papulosquamous disease that can be acquired or inherited. There have been reported cases of rheumatologic associations, mainly arthritis and dermatomyositis. In this review article, we will explore the clinical presentation and classification, rheumatologic associations and treatment...

Galectins: novel anti-inflammatory drug targets.

Published in Expert Opinion on Therapeutic Targets

Galectins are a protein family defined by their affinity for beta-galactosides and consensus sequences. They are pleiotropic regulators involved in a multitude of functions, both in and out of the cell. Extracellularly, they have the potential to bind to various surface receptors on a variety of cell types as well as extracellular matrix (ECM) prot...

Hedgehog signaling pathway mediates tongue tumorigenesis in wild-type mice but not in Gal3-deficient mice.

Published in Experimental and Molecular Pathology

Oral squamous cell carcinoma (OSCC) is one of the most aggressive cancers of the oral cavity and an important cause of death worldwide. Currently, there are limited clinical tools aiding clinicians to establish its early diagnosis, and genetic and epigenetic events leading to the pathogenesis of OSCC remain unsolved. The use of carcinogen-induced k...

Frontline Science: Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while pro...

Published in Journal of Leukocyte Biology