IgE-dependent mast cell activation potentiates airway responses in murine asthma models
Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology
Cell cycle regulation by galectin-12, a new member of the galectin superfamily
Published in JBIC Journal of Biological Inorganic Chemistry
Human galectin-3 is a novel chemoattractant for monocytes and macrophages
Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology
Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses
Published in American Journal Of Pathology
A role for IgE in airway secretions: IgE immune complexes are more potent inducers than antigen alone of airway inflamma...
Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology
Toxoplasma gondii infection reveals a dual role for galectin-3 on innate and adaptive immune response
Published in American Journal Of Pathology
The role of galectin-3 in promotion of the inflammatory response.
Published in Drug News & Perspectives
Galectin-3 is a member of a family of beta-galactoside-binding animal lectins and is distinct from other members by the presence of tandem repeats in its N-terminal region. Like other members, galectin-3 lacks a classical signal sequence, but the protein is secreted by a nonclassical secretary pathway and can function extracellularly in an autocrin...
Examination of galectins in phagocytosis.
Published in Methods in Molecular Biology
Galectins, a family of β-galactoside-binding proteins, are expressed in many different phagocytic leukocytes (granulocytes, monocytes, and macrophages). A number of family members have been shown to play an important role in ingestion of particles (phagocytosis), thus contributing to clearance of damaged cells and host defense against pathogens. He...
Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells.
Published in DNA and Cell Biology
AHAs (α-hydroxy acids), including glycolic acid (GA), have been widely used in cosmetic products and superficial chemical peels. Inflammasome complex has been shown to play critical roles in inflammatory pathways in human keratinocytes. However, the anti-inflammatory mechanism of GA is still unknown. The aim of this study is to investigate the rela...
Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insul...
Published in Proceedings of the National Academy of Sciences
The breakdown of triglycerides, or lipolysis, is a tightly controlled process that regulates fat mobilization in accord with an animal s energy needs. It is well established that lipolysis is stimulated by hormones that signal energy demand and is suppressed by the antilipolytic hormone insulin. However, much still remains to be learned about regul...
