Toxoplasma gondii infection reveals a dual role for galectin-3 on innate and adaptive immune response
Published in American Journal Of Pathology
The role of galectin-3 in promotion of the inflammatory response.
Published in Drug News & Perspectives
Galectin-3 is a member of a family of beta-galactoside-binding animal lectins and is distinct from other members by the presence of tandem repeats in its N-terminal region. Like other members, galectin-3 lacks a classical signal sequence, but the protein is secreted by a nonclassical secretary pathway and can function extracellularly in an autocrin...
Examination of galectins in phagocytosis.
Published in Methods in Molecular Biology
Galectins, a family of β-galactoside-binding proteins, are expressed in many different phagocytic leukocytes (granulocytes, monocytes, and macrophages). A number of family members have been shown to play an important role in ingestion of particles (phagocytosis), thus contributing to clearance of damaged cells and host defense against pathogens. He...
Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells.
Published in DNA and Cell Biology
AHAs (α-hydroxy acids), including glycolic acid (GA), have been widely used in cosmetic products and superficial chemical peels. Inflammasome complex has been shown to play critical roles in inflammatory pathways in human keratinocytes. However, the anti-inflammatory mechanism of GA is still unknown. The aim of this study is to investigate the rela...
Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insul...
Published in Proceedings of the National Academy of Sciences
The breakdown of triglycerides, or lipolysis, is a tightly controlled process that regulates fat mobilization in accord with an animal s energy needs. It is well established that lipolysis is stimulated by hormones that signal energy demand and is suppressed by the antilipolytic hormone insulin. However, much still remains to be learned about regul...
Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukem...
Published in ACS Nano
A recent finding reports that co-stimulation of the high-affinity immunoglobulin E (IgE) receptor (FcεRI) and the chemokine receptor 1 (CCR1) triggered formation of membrane nanotubes among bone-marrow-derived mast cells. The co-stimulation was attained using corresponding ligands: IgE binding antigen and macrophage inflammatory protein 1α (MIP1 α)...
Regulation of cellular homeostasis by galectins.
Published in Glycoconjugate Journal
Members of the galectin family are presently known to participate in cellular homeostasis by modulating cell growth, controlling cell cycle progression, and inducing or inhibiting apoptosis. Both intracellular and extracellular activities of galectins have been described, with the former typically independent of lectin activity, and the latter medi...
Regulatory roles of galectins in the immune response.
Published in International Archives of Allergy and Immunology
Galectins are a family of animal lectins with affinity for beta-galactosides. They are differentially expressed by various immune cells and their expression levels appear to be dependent on cell differentiation and activation. They can interact with cell-surface and extracellular matrix glycoconjugates (glycoproteins and glycolipids), through lecti...
Modulation of CD6 function through interaction with Galectin-1 and -3.
Published in FEBS Letters
CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian le...
B cell depletion therapy exacerbates murine primary biliary cirrhosis.
...Published in Hepatology
