Galectin-7 (PIG1:p53-induced gene 1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome...
Published in JBIC Journal of Biological Inorganic Chemistry
IgE-dependent mast cell activation potentiates airway responses in murine asthma models
Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology
Cell cycle regulation by galectin-12, a new member of the galectin superfamily
Published in JBIC Journal of Biological Inorganic Chemistry
Human galectin-3 is a novel chemoattractant for monocytes and macrophages
Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology
Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses
Published in American Journal Of Pathology
A role for IgE in airway secretions: IgE immune complexes are more potent inducers than antigen alone of airway inflamma...
Published in Journal of Japan Society of Immunology & Allergology in Otolaryngology
Toxoplasma gondii infection reveals a dual role for galectin-3 on innate and adaptive immune response
Published in American Journal Of Pathology
The role of galectin-3 in promotion of the inflammatory response.
Published in Drug News & Perspectives
Galectin-3 is a member of a family of beta-galactoside-binding animal lectins and is distinct from other members by the presence of tandem repeats in its N-terminal region. Like other members, galectin-3 lacks a classical signal sequence, but the protein is secreted by a nonclassical secretary pathway and can function extracellularly in an autocrin...
Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces prolifer...
Published in Journal of Biological Chemistry
Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA induces pro-inflammatory signals in a receptor-mediat...
Examination of galectins in phagocytosis.
Published in Methods in Molecular Biology
Galectins, a family of β-galactoside-binding proteins, are expressed in many different phagocytic leukocytes (granulocytes, monocytes, and macrophages). A number of family members have been shown to play an important role in ingestion of particles (phagocytosis), thus contributing to clearance of damaged cells and host defense against pathogens. He...
