A sweet target for innate immunity.
Published in Nature medicine
Published in Nature medicine
Published in Journal of Biological Chemistry
It has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling. We found that expression of alphavbeta3 enhanced IGF-1-induced proliferation of Chinese hamster ovary cells in serum-free conditions (in the absence of vitro...
Published in Proc Natl Acad Sci
Published in Journal of Investigative Dermatology Symposium Proceedings
Published in American Journal Of Pathology
Published in Immunological Reviews
Published in The Journal of biological chemistry
Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA induces pro-inflammatory signals in a receptor-mediat...
Published in The Journal of investigative dermatology
Neutrophil influx is an early inflammatory response that is essential for the clearance of bacteria and cellular debris during cutaneous wounding. A non-invasive real-time fluorescence imaging technique was developed to examine the kinetics of enhanced green fluorescence protein-polymorphonuclear leukocyte (EGFP-PMN) influx within a wound. We hypot...
Published in Journal of Investigative Dermatology Symposium Proceedings
Published in Expert Reviews in Molecular Medicine