A sweet target for innate immunity.
Published in Nature medicine
The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.
Published in Journal of Biological Chemistry
It has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling. We found that expression of alphavbeta3 enhanced IGF-1-induced proliferation of Chinese hamster ovary cells in serum-free conditions (in the absence of vitro...
Galectin-3 negatively regulates TCR-mediated CD4+ T cell activation at the immunological synapse
...Published in Proc Natl Acad Sci
Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells
Published in Journal of Investigative Dermatology Symposium Proceedings
Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis
Published in American Journal Of Pathology
Galectin-3 regulates T cells
Published in Immunological Reviews
Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces prolifer...
Published in The Journal of biological chemistry
Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA induces pro-inflammatory signals in a receptor-mediat...
Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging.
Published in The Journal of investigative dermatology
Neutrophil influx is an early inflammatory response that is essential for the clearance of bacteria and cellular debris during cutaneous wounding. A non-invasive real-time fluorescence imaging technique was developed to examine the kinetics of enhanced green fluorescence protein-polymorphonuclear leukocyte (EGFP-PMN) influx within a wound. We hypot...
Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation
Published in Journal of Investigative Dermatology Symposium Proceedings
Galectins: Structures, functions and therapeutic potential
Published in Expert Reviews in Molecular Medicine
