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News 74 Publications 6 Members

A sweet target for innate immunity.

Liu, Fu-Tong Bevins, Charles L

Published in Nature medicine

The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. PDF available through Get Fulltext Research

J, Saegusa S, Yamaji K, Ieguchi Cy, Wu Ks, Lam Ft, Liu Yk, Takada Y, Takada

Published in Journal of Biological Chemistry

It has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling. We found that expression of alphavbeta3 enhanced IGF-1-induced proliferation of Chinese hamster ovary cells in serum-free conditions (in the absence of vitro...

Galectin-3 negatively regulates TCR-mediated CD4+ T cell activation at the immunological synapse

Huan-Yuan Chen Fermin, A Vardhana, S Weng, I-C Lo, K F R Chang, E-Y Maverakis, E Ri-Yao Yang Daniel Hsu Dustin, M ...

Published in Proc Natl Acad Sci

Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells

Daniel Hsu Huan-Yuan Chen Lan Yu Chernyavsky, A I Grando, S A Fu-Tong Liu

Published in Journal of Investigative Dermatology Symposium Proceedings

Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis

Saegusa, J Daniel Hsu Huan-Yuan Chen Lan Yu Fermin, A Fung, M A Fu-Tong Liu

Published in American Journal Of Pathology

Galectin-3 regulates T cells

Daniel Hsu Huan-Yuan Chen Fu-Tong Liu

Published in Immunological Reviews

Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces prolifer... PDF available through Get Fulltext Research

Saegusa, Jun Akakura, Nobuaki Wu, Chun-Yi Hoogland, Case Ma, Zi Lam, Kit S Liu, Fu-Tong Takada, Yoko K Takada, Yoshikazu

Published in The Journal of biological chemistry

Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA induces pro-inflammatory signals in a receptor-mediat...

Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. PDF available through Get Fulltext Research

Kim, Min-Ho Liu, Wei Borjesson, Dori L Curry, Fitz-Roy E Miller, Lloyd S Cheung, Ambrose L Liu, Fu-Tong Isseroff, R Rivkah Simon, Scott I

Published in The Journal of investigative dermatology

Neutrophil influx is an early inflammatory response that is essential for the clearance of bacteria and cellular debris during cutaneous wounding. A non-invasive real-time fluorescence imaging technique was developed to examine the kinetics of enhanced green fluorescence protein-polymorphonuclear leukocyte (EGFP-PMN) influx within a wound. We hypot...

Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation

Saegusa, J Daniel Hsu Liu, W Kuwabara, I Kuwabara, Y Lan Yu Fu-Tong Liu

Published in Journal of Investigative Dermatology Symposium Proceedings

Galectins: Structures, functions and therapeutic potential

Ri-Yao Yang Rabinovich, G A Fu-Tong Liu

Published in Expert Reviews in Molecular Medicine

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