Engineered nanostructures of antigen provide an effective means for regulating mast cell activation.

Published in ACS nano

Nanostructures containing 2,4-dinitrophenyl (DNP) as antigen were designed and produced to investigate antibody-mediated activation of mast cells. The design consists of nanogrids of DNP termini inlaid in alkanethiol self-assembled monolayers (SAMs). Using scanning probe-based nanografting, nanometer precision was attained for designed geometry, si...

Galectin-3 and the skin.

Published in Journal of dermatological science

Galectin-3 is highly expressed in epithelial cells including keratinocytes and is involved in the pathogenesis of inflammatory skin diseases by affecting the functions of immune cells. For example, galectin-3 can contribute to atopic dermatitis (AD) by promoting polarization toward a Th2 immune response by regulating dendritic cell (DC) and T cell ...

Applications of atomic force microscopy in biophysical chemistry of cells.

Published in The journal of physical chemistry. B

This article addresses the question of what information and new insights atomic force microscopy (AFM) provides that are of importance and relevance to cellular biophysical chemistry research. Three enabling aspects of AFM are discussed: (a) visualization of membrane structural features with nanometer resolution, such as microvilli, ridges, porosom...

A sweet target for innate immunity.

Published in Nature medicine

The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.

Published in Journal of Biological Chemistry

It has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling. We found that expression of alphavbeta3 enhanced IGF-1-induced proliferation of Chinese hamster ovary cells in serum-free conditions (in the absence of vitro...

Galectin-3 negatively regulates TCR-mediated CD4+ T cell activation at the immunological synapse

Published in Proc Natl Acad Sci

Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells

Published in Journal of Investigative Dermatology Symposium Proceedings

Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis

Published in American Journal Of Pathology

Galectin-3 regulates T cells

Published in Immunological Reviews

Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces prolifer...

Published in The Journal of biological chemistry

Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA induces pro-inflammatory signals in a receptor-mediat...