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News 74 Publications 6 Members

Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori. PDF available through Get Fulltext Research

Park, Ah-Mee Hagiwara, Satoru Hsu, Daniel K Liu, Fu-Tong Yoshie, Osamu

Published in Infection and immunity

We studied the role of galectin-3 (Gal3) in gastric infection by Helicobacter pylori We first demonstrated that Gal3 was selectively expressed by gastric surface epithelial cells and abundantly secreted into the surface mucus layer. We next inoculated H. pylori Sydney strain 1 into wild-type (WT) and Gal3-deficient mice using a stomach tube. At 2 w...

Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs ... PDF available through Get Fulltext Research

Arsenijevic, Aleksandar Milovanovic, Marija Milovanovic, Jelena Stojanovic, Bojana Zdravkovic, Natasa Leung, Patrick S C Liu, Fu-Tong Gershwin, M Eric Lukic, Miodrag L

Published in Scientific reports

Galectin-3 (Gal-3) is a carbohydrate binding lectin, with multiple roles in inflammatory diseases and autoimmunity including its antiapoptotic effect on epithelial cells. In particular, increased expression of Gal-3 in epithelial cells is protective from apoptosis. Based on the thesis that apoptosis of biliary epithelial cells (BECs) is critical to...

Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling. PDF available through Get Fulltext Research

Chen, Hung-Lin Chiang, Po-Cheng Lo, Chia-Hui Lo, Yuan-Hsin Hsu, Daniel K Chen, Huan-Yuan Liu, Fu-Tong

Published in The Journal of investigative dermatology

Galectin-7, a member of the β-galactoside-binding protein family, is primarily expressed in stratified epithelial cells, including keratinocytes. There is information in the literature suggesting a role for this protein in regulation of keratinocyte survival and growth, but the underlying mechanism remains relatively unknown. Moreover, its expressi...

Patient-centered, direct-access online care for management of atopic dermatitis: a randomized clinical trial. PDF available through Get Fulltext Research

Armstrong, April W Johnson, Mary Ann Lin, Steven Maverakis, Emanual Fazel, Nasim Liu, Fu-Tong

Published in JAMA dermatology

New models of health care delivery for dermatological care have the potential to increase access and improve patient-centered outcomes. To compare effectiveness of a direct-access, online model for follow-up dermatologic care in pediatric and adult patients with atopic dermatitis with that of in-person office visits. This was a 1-year, randomized c...

Melanocytic galectin-3 is associated with tyrosinase-related protein-1 and pigment biosynthesis. PDF available through Get Fulltext Research

Chalupa, Allison Koshoffer, Amy Galan, Emily Yu, Lan Liu, Fu-Tong Boissy, Raymond E

Published in The Journal of investigative dermatology

Galectin-3 is a family member of the carbohydrate-binding proteins widely expressed by many cell types and exhibits multiple cellular functions. We demonstrate that melanocytes express galectin-3, which is predominantly localized to the cell body peripherally along the Golgi zone. Downregulation of galectin-3 in human melanocytes using short hairpi...

Galectin-3 Modulates Th17 Responses by Regulating Dendritic Cell Cytokines PDF available through Get Fulltext Research

Fermin Lee, Agnes Chen, Huan-Yuan Wan, Lei Wu, Sheng-Yang Yu, Jhang-Sian Huang, Annie C. Miaw, Shi-Chuen Hsu, Daniel K. Wu-Hsieh, Betty A. Liu, Fu-Tong ...

Published in The American Journal of Pathology

Galectin-3 is a β-galactoside–binding animal lectin with diverse functions, including regulation of T helper (Th) 1 and Th2 responses. Current data indicate that galectin-3 expressed in dendritic cells (DCs) may be contributory. Th17 cells have emerged as critical inducers of tissue inflammation in autoimmune disease and important mediators of host...

Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration. PDF available through Get Fulltext Research

Liu, Wei Hsu, Daniel K Chen, Huan-Yuan Yang, Ri-Yao Carraway, Kermit L 3rd Isseroff, Roslyn R Liu, Fu-Tong

Published in The Journal of investigative dermatology

The EGFR-mediated signaling pathways are important in a variety of cellular processes, including cell migration and wound re-epithelialization. Intracellular trafficking of EGFR is critical for maintaining EGFR surface expression. Galectin-3, a member of an animal lectin family, has been implicated in a number of physiological and pathological proc...

Pulmonary Effects of Diesel Exhaust PDF available through Get Fulltext Research

Kenyon, Nicholas Liu, Fu-Tong

Published in The American Journal of Pathology

This commentary highlights the article by Kim et al that describes the pulmonary effects of diesel exhaust including exacerbation of asthma, increased expression of chemokines, and inflammation.

IgE, Mast Cells, and Eosinophils in Atopic Dermatitis

Liu, Fu-Tong Goodarzi, Heidi Chen, Huan-Yuan

Published in Clinical Reviews in Allergy & Immunology

Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This review focuses on the role of IgE, mast cells, and eosinophils in the p...

Engineered nanostructures of antigen provide an effective means for regulating mast cell activation.

Deng, Zhao Weng, I-Chun Li, Jie-Ren Chen, Huan-Yuan Liu, Fu-Tong Liu, Gang-yu

Published in ACS nano

Nanostructures containing 2,4-dinitrophenyl (DNP) as antigen were designed and produced to investigate antibody-mediated activation of mast cells. The design consists of nanogrids of DNP termini inlaid in alkanethiol self-assembled monolayers (SAMs). Using scanning probe-based nanografting, nanometer precision was attained for designed geometry, si...

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